Artículos de revistas
Leptin levels are associated with immune response in malnourished infants
Fecha
2002Registro en:
Journal of Clinical Endocrinology and Metabolism, Volumen 87, Issue 7, 2018, Pages 3040-3046
0021972X
10.1210/jcem.87.7.8636
Autor
Palacio, Ana
López, Marcelo
Pérez Bravo, Francisco
Monkeberg, Fernando
Schlesinger, Liana
Institución
Resumen
Circulating leptin levels, proinflammatory and T helper cells type 1 (Th1), Th2 cytokine production, and lymphoproliferative response were measured in 15 infants with primary moderate protein calorie malnutrition on admission and after recovery of 10% of weight. Sixteen healthy, well nourished infants of comparable age served as controls. A significant deficit in the z-score of weight for age, weight for height, body mass index, and circulating leptin and growth factors were detected in malnourished infants on admission compared with controls (P < 0.05). These deficits were associated with a significant suppression of the lymphoproliferative response, Th1, and proinflammatory cytokine production (P < 0.05). After a 10% weight gain, a significant increase in circulating leptin levels was produced in parallel with a significant increase in Th1 activity, as revealed by an enhancement in interferon-γ and a suppression in IL-4 production. Concomitantly, the lymphoproliferative response beca