Artículo de revista
A gene family encoding heterogeneous histone H1 proteins in Trypanosoma cruzi
Fecha
1994Registro en:
Molecular and Biochemical Parasitology, Volumen 65, Issue 2, 2018, Pages 317-330
01666851
10.1016/0166-6851(94)90082-5
Autor
Åslund, Lena
Carlsson, Lars
Henriksson, Jan
Rydåker, Maria
Cecilia Toro, G.
Galanti Garrone, Norbel
Pettersson, Ulf
Institución
Resumen
A gene family encoding a set of histone H1 proteins in Trypanosoma cruzi is described. The sequence of 3 genomic and 4 cDNA clones revealed the presence of several motifs characteristic of histone H1 although heterogeneity at the polypeptide level was evident. The clones encode histone H1 proteins of an unusually small size (74-97 amino acids) which lack the globular domain found in histone H1 of higher eukaryotes. All histone H1 mRNAs from T. cruzi are polyadenylated although no typical polyadenylation signal was found. Furthermore the genes encoding the histone H1 proteins in T. cruzi are found in a tandem array containing 15-20 gene copies per haploid genome. This tandem array is located on a large chromosome of 2.2 Mb. © 1994.