Artículos de revistas
Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi
Fecha
1991Registro en:
FEBS Letters, Volumen 295, Issue 1-3, 2018, Pages 31-34
00145793
10.1016/0014-5793(91)81377-K
Autor
Rojas, M.Verónica
Galanti Garrone, Norbel
Institución
Resumen
5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division. © 1991.