Artículo de revista
Measurement of interaction parameters between glutathione and β-lactam antibiotics : a polarographic approach
Date
1988Registration in:
European Journal of Medicinal Chemistry, Volumen 23, Issue 6, 2018, Pages 573-575
17683254
02235234
10.1016/0223-5234(88)90101-8
Author
Núñez Vergara, Luis
Squella Serrano, Juan
Institutions
Abstract
The interaction of glutathione with four β-lactam antibiotics was studied by an AC polarographic procedure. The interaction stability constant and the coordination number were calculated from the AC polarographic data. The results underscore the importance of polarography as a tool for the study of biologically significant interactions and suggest a previously undescribed biótransformation pathway for β-lactam antibiotics. © 1988.