Artículo de revista
Turnover of hepatic glutathione after acute lindane intoxication
Fecha
1993Registro en:
Toxicology Letters, Volumen 69, Issue 2, 1993, Pages 211-216
03784274
10.1016/0378-4274(93)90106-8
Autor
Junqueira, Virginia
Barros, Silvia B.M.
Simizu, Kiyoko
Fernández Arancibia, Virginia
Carrión, Yasna
Pimentel, Renato
Azzalis, Ligia A.
Videla Cabrera, Luis
Institución
Resumen
The administration of lindane (60 mg/kg) to fed rats diminished the content of hepatic glutathione (GSH)
4 h after treatment, which was recovered at 24 h. At these experimental times, the activities of glutathione
peroxidase, glutathione reductase, glutathione-4transferases and y-glutamyltransferase in the liver of
lindane-treated rats and control animals were comparable. Liver GSH turnover, measured after a pulse of
[3sS]cysteine, was enhanced by 69% (P < 0.05) in &lane-treated rats 24 h after intoxication compared to
controls, with a 63% (P < 0.05) increase in the estimated rate of CSH synthesis. It is concluded that lindane
enhances GSH synthesis in rat liver 24 h after treatment as a consequence of the decrement in its content
observed at early times of intoxication (4 h), thus allowing the recovery of the normal level of hepatic GSH.