Artículos de revistas
Rational development of a novel hydrogel as a pH-sensitive controlled release system for nifedipine
Fecha
2018Registro en:
Polymers, Volumen 10, Issue 7, 2018,
20734360
10.3390/polym10070806
Autor
Avila-Salas, Fabián
Rodriguez Nuñez, Yeray A.
Marican, Adolfo
Castro, Ricardo I.
Villaseñor, Jorge
Santos, Leonardo S.
Wehinger, Sergio
Durán-Lara, Esteban F.
Institución
Resumen
© 2018 by the authors. This work depicts the rational development (in-silico design, synthesis, characterization and in-vitro evaluation) of polyvinyl alcohol hydrogels (PVAH) cross-linked with maleic acid (MA) and linked to γ-cyclodextrin molecules (γ -CDPVAHMA) as systems for the controlled and sustained release of nifedipine (NFD). Through computational studies, the structural blocks (PVA chain + dicarboxylic acid + γ-CD) of 20 different hydrogels were evaluated to test their interaction energies (ΔE) with NFD. According to the DE obtained, the hydrogel cross-linked with maleic acid was selected. To characterize the intermolecular interactions between NFD and γ-CDPVAHMA, molecular dynamics simulation studies were carried out. Experimentally, three hydrogel formulations with different proportions of γ-CD (2.43%, 3.61% and 4.76%) were synthesized and characterized. Both loading and release of NFD from the hydrogels were evaluated at acid and basic pH. The computational and experimenta