Artículo de revista
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Fecha
2014Registro en:
Journal of Hypertension, Volumen 32, Issue 4, 2018, Pages 771-783
14735598
02636352
10.1097/HJH.0000000000000094
Autor
Ocaranza, Maria Paz
Moya, Jackeline
Barrientos, Victor
Alzamora, Rodrigo
Hevia, Daniel
Morales, Cristobal
Pinto, Melissa
Escudero, Nicolás
García Nannig, Lorena
Novoa, Ulises
Ayala, Pedro
Díaz Araya, Guillermo
Godoy, Ivan
Chiong Lay, Mario
Lavandero González, Sergio
Jalil Milad, Jorge
Institución
Resumen
BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: In this study, we evaluated whether angiotensin-(1-9) decreases hypertension and reverses experimental cardiovascular damage in the rat. METHODS AND RESULTS:: Angiotensin-(1-9) (600 ng/kg per min for 2 weeks) reduced already-established hypertension in rats with early high blood pressure induced by angiotensin II infusion or renal artery clipping. Angiotensin-(1-9) also improved cardiac (assessed by echocardiography) and endothelial function in small-diameter mesenteric arteries, cardiac and aortic wall hypertrophy, fibrosis, oxidative stress, collagen and transforming growth factor type β - 1 protein expression (assessed by western blot). The beneficial effect of angiotensin-(1-9) was blunted by coadministration of the angiotensin type 2(AT2) receptor blocker PD123319
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