Artículos de revistas
Voltammetric study and direct analytical determination of the antiparkinson drug benserazide
Fecha
2011Registro en:
Analytical Letters, Volumen 44, Issue 9, 2011, Pages 1683-1698
00032719
1532236X
10.1080/00032719.2010.520395
Autor
Pérez-Ortiz, M.
Bollo Dragnic, Soledad
Zapata Urzúa, Claudio Andrés
Yáñez, C.
Álvarez Lueje, Alejandro
Institución
Resumen
For the first time, a simple differential pulse voltammetry methodology for direct determination of benserazide in presence of levodopa in tablets was developed without any redox mediator, modified electrodes, or the aplication of mathematic deconvolution of signals. Benserazide was studied by differential pulse voltammetry using glassy carbon electrode in aqueous media. The drug exhibited a main well-defined oxidation signal in a broad pH range (2-10), and two poorly resolved signals at higher potentials. We have found that levodopa does not interfere on the electrochemical response of benserazide at pH 6.0. Thus, at this pH value, the developed analytical method exhibited adequate repeatability and reproducibility (RSD<2%), recoveries >98.5%, which permitted its successful application to both the assay and the uniformity content of benserazide. Also, hydrolytic degradation studies of benserazide were carried out by differential pulse voltammetry.