Artículos de revistas
Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry
Fecha
1999Registro en:
International Journal of Pharmaceutics, Volumen 189, Issue 1, 2018, Pages 67-74
03785173
10.1016/S0378-5173(99)00238-0
Autor
Toral Ponce, María
Richter Duk, Pablo
Lara, Nelson
Jaque, Pablo
Soto, Cesar
Saavedra, Marcela
Institución
Resumen
A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.