Starvation effect on rat kidney peroxisomal and microsomal fatty acid oxidation. A comparative study between liver and kidney

Abstract

Microsomal lauric acid 12-hydroxy lauric acid (ω)-hydroxylation and fatty acid peroxisomal β-oxidation were studied in kidney tissue from starved rats. Starvation increased the microsomal ω-hydroxylation and peroxisomal β-oxidation of fatty acids with a high correlation between both processes. Earlier, we reported similar results in liver. Our results support the hypothesis that the role of microsomal fatty acids ω-hydroxylation is the generation of substrate for peroxisomal β-oxidation, with the final purpose of contributing to a catabolic or gluconeogenic pathway from fatty acids. © 1993.