Increased expression of c-rel, from the NF-κB/Rel family, in T cells from patients with systemic lupus erythematosus

Abstract

OBJECTIVE: To explore the role of the NF - kappaB/Rel transcription factor family in autoimmunity, we investigated whet her peripheral blood mononuclear cells (PBMC) and T cells from the blood of patients with systemic lupus erythematosus (SLE) exhibit abnormal expression of c - rel, both when recently isolated and/or during in vitro activation.