Artículos de revistas
VCD determination of the absolute configuration of stypotriol
Fecha
2009Registro en:
Natural Product Communications Vol. 4 (8) 2009
1934578X
15559475
Autor
Muñoz, Marcelo A.
Areche Medina, Carlos
San Martín Barrientos, Aurelio
Rovirosa, Juana
Joseph-Nathan, Pedro
Institución
Resumen
The absolute configuration of the pentacyclic ichthyotoxin stypotriol, a constituent of Stypopodium zonale, was deduced to be 3S,5R,8R,9R,10S,13S,14S-(-) -1 by vibrational circular dichroism spectroscopy of the derived triacetate 2 in comparison to DFT B3LYP/DGDZVP calculations. Compound 2, C33H46O7 having 300 electrons, is the largest natural product successfully studied by VCD to date.