Artículo de revista
Theoretical study of the C‐ vs. O‐Acylation of metal enolates. Frontier molecular orbital analysis including solvent effects
Fecha
1993Registro en:
International Journal of Quantum Chemistry, Volumen 48, Issue 27 S, 2018, Pages 713-721
1097461X
00207608
10.1002/qua.560480863
Autor
Saragoni, Victor G.
Contreras Ramos, Renato
Aizman, Arie
Institución
Resumen
An extended version of the Klopman–Salem equation of chemical reactivity, which incorporates the effect of an external electrostatic field in both charge and orbital contributions, has been applied to analyze the reactivity pattern of ambident metal enolates towards acylation reactions in different solvents. The results are consistent with the experimental observation that the proportion of C‐acylation product is enhanced for solvents of low polarity where a relevant orbital control contribution is predicted. Comparison between the cis/trans proportion of C‐ and O‐acylation products are also qualitatively accounted for by the FMO analysis. © 1993 John Wiley & Sons, Inc. Copyright © 1993 John Wiley & Sons, Inc.