Artículos de revistas
Medicinal plants of Chile: Evaluation of their anti-trypanosoma cruzi activity
Fecha
2013Registro en:
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Volumen 68 C, Issue 5-6, 2018, Pages 198-202
09395075
10.1515/znc-2013-5-605
Autor
Muñoz, Orlando M.
Maya Arango, Juan
Ferreira, Jorge
Christen, Philippe
San Martín, José
López Muñoz, Rodrigo
Morello Casté, Antonio
Kemmerling Weis, Ulrike
Institución
Resumen
The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 μg/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T. cruzi with IC50 values of 27.9 and 25.1 μM, respectively. © 2013 Verlag der Zeitschrift für Naturforschung, Tübingen.