Artículos de revistas
Structural reassignment of epierythratidine, an alkaloid from Erythrina fusca, based on NMR studies and computational methods
Fecha
2012Registro en:
Journal of the Chilean Chemical Society, Volumen 57, Issue 3, 2018, Pages 1323-1327
07179707
07179324
10.4067/S0717-97072012000300027
Autor
García Beltrán, Olimpo
Soto Delgado, Jorge
Iturriaga-Vásquez, Patricio
Areche, Carlos
Cassels Niven, Bruce
Institución
Resumen
The diene Erythrina alkaloids erysotrine (1), erysodine (2), erythraline (3), erytharbine (4), and erysotrine N-oxide (5), plus the hydroxylated dihydro derivative of 1, epierythratidine (6) were isolated from seeds of Erythrina fusca Lour., and their 1H and 13C NMR spectra were completely assigned using 2D experiments (H-H COSY, HMQC, HMBC and H-H NOESY). Our assignments for 1-5 agree well with the literature, but the present work shows that the published interpretation of the spectra of 6 must be revised. A combined study based on NMR data and quantum-mechanical calculations using DFT/GIAO indicate that 6 is the correct structure of epierythratidine.