dc.creator | Rohatgi, Soma | |
dc.creator | Nakouzi, Antonio | |
dc.creator | Carreño Marquez, Leandro J. | |
dc.creator | Slosar-Cheah, Magdalena | |
dc.creator | Kuniholm, Mark H. | |
dc.creator | Wang, Tao | |
dc.creator | Pappas, Peter G. | |
dc.creator | Pirofski, Liise-anne | |
dc.date.accessioned | 2018-07-30T20:09:27Z | |
dc.date.available | 2018-07-30T20:09:27Z | |
dc.date.created | 2018-07-30T20:09:27Z | |
dc.date.issued | 2018 | |
dc.identifier | Open Forum Infectious Diseases Volumen: 5 Número: 1 Número de artículo: UNSP ofx255 | |
dc.identifier | 10.1093/ofid/ofx255 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/150455 | |
dc.description.abstract | The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis. | |
dc.language | en | |
dc.publisher | Oxford University Press | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Open Forum Infectious Diseases | |
dc.subject | Antibody immunity | |
dc.subject | B cell subsets | |
dc.subject | Cryptococcus neoformans | |
dc.subject | HIV-associated cryptococcosis | |
dc.subject | Memory B cells | |
dc.title | Antibody and B Cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis | |
dc.type | Artículo de revista | |