Artículo de revista
Antibody and B Cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis
Fecha
2018Registro en:
Open Forum Infectious Diseases Volumen: 5 Número: 1 Número de artículo: UNSP ofx255
10.1093/ofid/ofx255
Autor
Rohatgi, Soma
Nakouzi, Antonio
Carreño Marquez, Leandro J.
Slosar-Cheah, Magdalena
Kuniholm, Mark H.
Wang, Tao
Pappas, Peter G.
Pirofski, Liise-anne
Institución
Resumen
The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.