Artículos de revistas
On the role of mining exposure in epigenetic effects in parkinson’s disease
Fecha
2017Registro en:
Neurotox Res (2017) 32:172–174
10.1007/s12640-017-9736-7
Autor
Castillo, Sebastián
Muñoz, Patricia
Behrens Pellegrino, María Isabel
Díaz Grez, Fernando
Segura Aguilar, Juan
Institución
Resumen
To explore the possible influence of heavy metal
mining on incidence of Parkinson’s disease (PD), global
DNA methylation was assessed in blood samples from a population
of PD patients (n = 45) and control subjects (n = 52) in
Antofagasta neighborhood, a Chilean city built for exclusive
use of mining companies. Comparisons were made with PD
subjects (n = 52) and control subjects (n = 59) from Santiago
Chile, a city having little association with mining. All subjects
were assessed by two neurologists and PD diagnosis was
based on UK Parkinson’s Disease Society Brain Bank
Clinical Diagnostic Criteria. From blood samples obtained
from each individual, a decrease in global DNA methylation
was observed in PD patients either exposed (49% of control,
P < 0.001) or not exposed (47% of control, P < 0.001) to
mining activity. Although there was no difference in levels
of DNA methylation between PD patients from the two cities,
there was a lower level of DNA methylation in control subjects
from Santiago versus Antofagasta.