Artículo de revista
Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry
Fecha
2016Registro en:
J. Braz. Chem. Soc., Vol. 27, No. 10, 1744-1749, 2016.
0103-5053
10.5935/0103-5053.20160055
Autor
iordano, Ady
Vásquez, José
Retamal, Mauricio
Ascar Estay, María Loreto
Institución
Resumen
The use of thin-film microextraction for the extraction of selected pharmaceutical compounds followed by gas chromatography-mass spectrometry detection was evaluated. A segment of polysiloxanes polymer sheet was used as low cost, single use, disposable extraction phase, while Milli-Q water spiked at 20 mu g L-1 with the analytes was used for the optimization assays. The controlling parameters for the extraction were optimized via experimental design and it was found that an extraction time of 3 h using a sample volume of 1000 mL at pH 4 with the addition of 20% methanol and 20% sodium chloride provided the greatest extraction efficiency. Recoveries between 67.1 and 85.0% were achieved, with a repeteability lower than 20% (expressed as coefficient of variation) and limit of detection ranged from 0.41 and 0.92 mu g L-1. The proposed method show similar analytical performance when compared to the determination of the analytes using stir bar sorptive extraction