Artículo de revista
Synergistic effect of copper and low temperature over Listeria monocytogenes
Fecha
2015Registro en:
Biometals (2015) 28:1087–1092
DOI 10.1007/s10534-015-9891-3
Autor
Latorre Mora, Mauricio
Quesille Villalobos, Ana María
Maza, Felipe
Parra, Angel
Reyes Jara, Angélica
Institución
Resumen
The capacity to grow at low temperatures has allowed Listeria monocytogenes to become one of the primary food pathogens to date, representing a major public health problem worldwide. Several works have described the homeostatic response of L. monocytogenes under different copper (Cu) treatments growing at mild temperature (30 degrees C). The aims of this report were to evaluate if changes in the external concentration of Cu affected viability and Cu homeostasis of L. monocytogenes growing at low temperature. Ours results showed that L. monocytogenes growing at 8 degrees C had a reduced viability relative to 30 degrees C when exposed to Cu treatments. This decrease was correlated with an increase in the internal concentration of Cu, probably linked to the transcriptional down-regulation of mechanisms involved in Cu homeostasis. This combined effect of Cu and low temperature showed a synergistic impact over the viability and homeostasis of L. monocytogenes, where low temperature exacerbated the toxic effect of Cu. These results can be useful in terms of the use of Cu as an antibacterial agent.