Artículo de revista
Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease
Fecha
2015Registro en:
Int. J. Mol. Sci. 2015, 16, 25168-25198
1422-0067
DOI: 10.3390/ijms161025168
Autor
Hernández Rodas, María Catalina
Valenzuela Báez, Rodrigo
Videla Cabrera, Luis
Institución
Resumen
Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease
worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance,
obesity, hyperlipidemia, and hypertension. Since the obesity figures and related
comorbidities are increasing, NAFLD has turned into a liver problem that has become
progressively more common. Currently, there is no effective drug therapy for NAFLD;
therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that
adherence rates to this type of treatment are poor, great efforts are currently focused on
finding novel therapeutic agents for the prevention in the development of hepatic steatosis
and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a
compilation of the scientific evidence found in the last years showing the results of
interventions in lifestyle, diet, and behavioral therapies and research results in human,
animal and cell models. Possible therapeutic agents ranging from supplementation with
vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and
polyphenols to interventions with medicinal plants are analyzed