Artículo de revista
Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus
Fecha
2015Registro en:
Journal of Neuroimmunology 287 (2015) 1–8
DOI: 10.1016/j.jneuroim.2015.07.006
Autor
González Gronow, Mario
Cuchacovich Turteltaub, Miguel
Francos, Rina
Cuchacovich, Stephanie
Blanco, Ángel
Sandoval, Rodrigo
Farías Gómez, Cristian
Valenzuela, Javier
Ray, Rupa
Pizzo, Salvatore
Institución
Resumen
Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the
brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of
both the IgG and IgA classes in high titers, but no autoantibodies of the IgMclass. IgA autoantibodies act as serine
proteinases and degradeMBP in vitro. They also induce a decrease in long-termpotentiation in the hippocampi of
rats either perfusedwith or previously inoculated with this IgA. Because this class of autoantibody causes myelin
sheath destruction in multiple sclerosis (MS), we hypothesized a similar pathological role for them in ASD.