Ionic liquids for improving the extraction of NSAIDs in water samples using dispersive liquid–liquid microextraction by high performance liquid chromatography-diodearray–fluorescence detection

Abstract

A rapid,sensitive and efficient analytical method base dont heuse of ionic liquids for determination of non-steroidalanti-inflammatory drugs(NSAIDs)in water samples was developed. High-performance liquid chromatography equipped with a diode array and fluorescence detector was used for quantification of ketoprofen, ibuprofen and diclofenacin tap and river water samples. This new method relies on the use of two ionic liquids with multiple functionalities: one functions as an extraction solvent(1-butyl- 3-methylimidazoliumhexafluorophosphate ([BMIM][PF6]), and the other changes the polarityinthe aqueousmedium(1-butyl-3-methylimidazoliumtetrafluoroborate,([BMIM][BF4]). Factors such as the type and volume of the ILs and dispersive solvent, sample volume, and centrifugation time were investigated and optimized. The optimized method exhibited good precision, with relative standard deviation values between 2% and 3%, for the three NSAIDs. Limits of detection achieved for all of the analytes were between 17 and 95ng mL 1, and the recoveries ranged from 89% to 103%.Furthermore, the enrichment factors ranged from 49 to 57. The proposed method was successfully applied to the analysis of NSAIDs in tap and river water samples.