Artículo de revista
Plasma Urate in REM Sleep Behavior Disorder
Fecha
2013Registro en:
Movement Disorders, Vol. 28, No. 8, 2013
DOI: 10.1002/mds.25441
Autor
Uribe San Mart, Reinaldo
Venegas Francke, Pablo
López Illanes, Felipe
Gazmuri Jones, Alex
Salazar Rivera, Julio
Godoy Fernández, Jaime
Santín Martínez, Julia
Juri, Carlos
Institución
Resumen
Background: Rapid eye movement (REM) sleep behavior
disorder (RBD) is associated with a high risk of
developing Parkinson’s disease (PD). Higher urate levels
are associated with a lower risk of PD. We conducted a
study to evaluate plasma urate levels in patients with
RBD and their role in the development of PD.
Methods: We evaluated plasma urate levels in a cohort
of 24 patients with idiopathic RBD. Patients were
divided into 2 groups according to the presence or
absence of PD. Other known markers of the risk of
developing PD, such as olfaction testing, and substantia
nigra (SN) hyperechogenicity, were evaluated in the
2 groups.
Results: No differences were observed regarding age,
years of evolution of the RBD, SN hyperechogenicity,
or plasma urate levels between the 2 groups. In
patients without PD, there was a positive correlation
between years of evolution of RBD and the levels of
uric acid (R250.88). Patients without PD and those
who had more than 5 years of RBD exhibited higher
levels of uric acid than patients with PD (P50.02).
Conclusions: Higher levels of plasma urate were associated
with a longer duration of RBD without converting
to PD. Future prospective studies would be
needed to confirm this finding. Disorder Society.