Artículos de revistas
Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
Fecha
2011-03Registro en:
REVISTA MEDICA DE CHILE Volume: 139 Issue: 3 Pages: 334-339 Published: MAR 2011
0034-9887
Autor
Delucchi Bicocchi, María Angela
Alarcón, Claudia
Cano Schuffeneger, Francisco
Lillo Durán, Ana
Guerrero, José Luis
Azócar Pruyas, Marta
Abarzúa, Carolina
Muñoz, María José
Iñíguez Vila, Germán
Institución
Resumen
Background: Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD). Aim: To determine the prevalence of 25 hydroxy vitamin D (25(OH)D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material and Methods: Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 +/- 4.6 years (51% females). Results: Fifty four percent of patients had height Z score less than - 1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 +/- 2.8 years. Mean 25(OH)D levels in all was 18.7 +/- 10.7 ng/ml (HD: 21 +/- 16.8, PD: 18.9 +/- 8.5, Tx: 18.1 +/- 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 +/- 0.64 mg/dl, serum phosphorus 5.03 +/- 1.02 mg/dl, calcium-phosphorus product 48 +/- 11.8 mg/dl and alkaline phosphatases 300.5 +/- 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 +/- 640.5 and 107.7 +/- 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH)D and calcium levels among PD patients was observed (r = 0.490, p = 0.04). Conclusions: Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.