Artículo de revista
Ovulation rate in adolescents with type 1 diabetes mellitus
Fecha
2011-01Registro en:
Fertility and Sterility, Vol. 95, No. 1, January 2011
doi:10.1016/j.fertnstert.2010.10.041
Autor
Codner Dujovne, Ethel
Eyzaguirre, Francisca
Iñíguez Vila, Germán
López, Patricia
Pérez Bravo, Francisco
Torrealba, Isabel M.
Cassorla Goluboff, Fernando
Institución
Resumen
Objective: To study ovulation in adolescents with type 1 diabetes (T1D) and the effect of hemoglobin A1c (HbA1c)
levels on their ovulatory function.
Design: Prospective investigation.
Setting: Academic research institute.
Patient(s): Adolescents with T1D (n ¼ 31) and healthy girls (n ¼ 52).
Intervention(s): Ovulation assessed through the measurement of salivary progesterone (days 13, 18, 23, and 28 of
each cycle).
Main Outcome Measure(s): Proportion of ovulatory cycles.
Result(s): Atotal of 168 and 281 menstrual cycles were studied in the T1D and control girls, respectively. Metabolic
control was defined as optimal if HbA1c was <7.5%. The proportion of ovulatory cycles was similar in the TID and
control groups (34.5% and 36.3%, respectively). Regression analyses showed that the presence of T1D did not have
a statistically significant effect on the ovulatory rate. However, more ovulatory cycles were observed in girls with
T1D who had optimal metabolic control compared with those who had insufficient control (51.3% vs. 29.4%).
Conclusion(s): In adolescent girls, T1D did not affect the rate of ovulation. A higher ovulatory rate was observed in
those with optimal control compared with those with insufficient metabolic control, but a substantial proportion of
ovulatory cycles were still observed in patients with higher HbA1c levels.