Artículo de revista
Leuprolide acetate gonadotrophin response patterns during female puberty
Fecha
2010Registro en:
Clinical Endocrinology (2010) 72, 489–495
doi: 10.1111/j.1365-2265.2009.03735.x
Autor
Martínez Aguayo, Alejandro
Mericq, Verónica
Hernández Cárdenas, María Isabel
Capurro Spadaro, María Teresa
Peña Novoa, Verónica
Ávila, Alejandra
Salazar, T.
Asenjo, S.
Iñíguez Vila, Germán
Institución
Resumen
Objective To assess normative data and the usefulness of spontaneous
and LHRH analogue-stimulated serum LH and FSH levels
measured by immunoradiometric assays (IRMA) in the evaluation
of normal puberty.
Design Prospective. Healthy girls in Tanner I and Tanner II
from the local community were invited to participate
(n = 47).
Methods A leuprolide acetate test (500 mcg/m2; sc) was performed.
LH and FSH levels were determined using IRMA. Tanner
II girls were assessed every 6 months until Tanner V. Girls
who progressed from Tanner II to Tanner III in the next
6 months were called Tanner II-2; otherwise, they were called
Tanner II-1.
Results The prepubertal upper limit (CI 95%) was 0Æ49 IU/l for
basal LH and 5Æ1 IU/l for stimulated LH. Taking into account these
LH cut-off limits, 72Æ2% and 66Æ7% of Tanner II-1 and 41Æ6% and
41Æ7% of Tanner II-2 subjects presented overlapping values for
basal and stimulated LH, respectively, as compared with the Tanner
I group. The cut-offs for basal and stimulated LH to predict progression
from Tanner II to Tanner III in the next 6 months were a
basal LH level ‡0Æ49 IU/l (Sensitivity = 0Æ58; 1-Specificity = 0Æ33)
and a poststimulated LH level ‡4Æ75 IU/l (Sensitivity = 0Æ67;
1-Specificity = 0Æ44).
Conclusion According to an IRMA, the basal and leuprolide acetate
gonadotrophin response patterns during the beginning stages
of puberty overlapped between Tanner I and Tanner II, and the
cut-offs of basal and stimulated LH levels to predict progress from
Tanner II to Tanner III had low sensitivities for the following
6 months.