Artículo de revista
Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox
Fecha
2008Registro en:
AGENTS AND CHEMOTHERAPY Volume: 52 Issue: 5 Pages: 1837-1839 Published: MAY 2008
0066-4804
10.1128/AAC.01454-07
Autor
Faúndez, Mario
López Muñoz, Rodrigo
Torres, Gloria
Morello Casté, Antonio
Ferreira, Jorge
Kemmerling Weis, Ulrike
Orellana Bown, Myriam
Maya Arango, Juan
Institución
Resumen
L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.