Artículo de revista
Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
Fecha
2008-11Registro en:
REVISTA MEDICA DE CHILE Volume: 136 Issue: 11 Pages: 1371-1380 Published: NOV 2008
0034-9887
Autor
Moraga, Francisco
Troncoso, Rodrigo
Mellado, Rose Marie
Díaz Araya, Guillermo
Vukasovic Ramírez, José Luis
Greig, Douglas
Pérez, Osvaldo
García Nannig, Lorena
Roldán, Juan
Ocaranza, María Paz
Jalil Milad, Jorge
Chiong Lay, Mario
Castro, Pablo
Institución
Resumen
Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important pharmacological targets. Aim: To evaluate genotype and gene-gene interaction between beta(1)-AR Arg389Gly and beta(2)-AR Arg16Gly, Gln27Glu and Thr1641le polymorphisms, as risk factors for HF, Material and methods: Eighty chronic HF patients and eighty-eight controls matched by age and sex were genotyped for beta(1)-AR Arg389Gly, beta(2)-AR Arg16Gly, Gln27Glu and Thr1641le polymorphisms. Results. The presence of beta(2)-AR Glu allele was a risk predictor for HF (odds ratio (OR) = 2.81; 95% confidence intervals (CI) = 1.49-5.31). Interactions that increased the risk for HF were found in patients carrying at least one of the beta(2)-AR Glu and beta(2)-AR Gly allele (OR = 3.81: 95% CI = 1.50-0.70) and beta(2)-AR Glu and beta(1)-AR Gly allele combination (OR = 5.51; 95% CI = 2.19-13.86). Furthermore, the frequency of beta(2)-AR Gly allele was higher among patients with a history of acute myocardial infarction (with infarction: 0.534, without: 0.313, p=0.01). Conclusions: beta(2)-AR Gly allele could be a risk predictor for HF. This risk could be enhanced by the additional presence of beta(2)-AR Gly16 or beta(1)-AR Arg389 alleles. The frequency of beta(2)-AR Gln27 Glu allele was higher among patients with a history of myocardial infarction.