Prediction of protein retention in hydrophobic interaction chromatography

dc.creatorMahn Osses, Andrea
dc.creatorAsenjo de Leuze, Juan
dc.date.accessioned2007-05-18T19:27:43Z
dc.date.available2007-05-18T19:27:43Z
dc.date.created2007-05-18T19:27:43Z
dc.date.issued2005-07
dc.identifierBIOTECHNOLOGY ADVANCES 23 (5): 359-368 JUL 2005
dc.identifier0734-9750
dc.identifierhttps://repositorio.uchile.cl/handle/2250/127197
dc.description.abstractHydrophobic interaction chromatography (HIC) is a powerful technique for protein separation. This review examines methodologies for predicting protein retention time in HIC involving elution with salt gradients. The methodologies discussed consider three-dimensional structure data of the protein and its surface hydrophobicity. Despite their limitations, the methods discussed are useful in designing purification processes for proteins and easing the tedious experimental work that is currently required for developing purification protocols.
dc.languageen
dc.publisherPERGAMON-ELSEVIER SCIENCE
dc.subjectDOCKING
dc.titlePrediction of protein retention in hydrophobic interaction chromatography
dc.typeArtículo de revista


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