Artículos de revistas
RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NF kappa B-dependent mechanism
Fecha
2008-08-18Registro en:
CANCER LETTERS, V. 267, N° 1, pp. 125-132, 2008
0304-3835
Autor
Tobar, Nicolás
Cáceres, Mónica
Santibáñez, Juan Francisco
Smith, Patricio C.
Martínez, Jorge
Institución
Resumen
modulate the migratory properties in MCF-7 and T47D human mammary cell lines. We also described that the NFjB
pathway exerts a downstream control on the expression of the ROS-dependent cellular migratory potential. These results
emphasize the importance of redox balance in the acquisition of malignancy and support previous data sustaining that an
oxidative environment predisposes cells to activate signal-transduction pathways actively involved in cellular oncogenesis.
Our data also provides evidence that NADPH oxidase could constitute the main source of intracellular ROS in response to
changes in Rac1 activity. We suggest that Rac1 plays a role in cellular migration not only limited to its known function in
reorganization of the actin cytoskeleton, but also as part of the intracellular machinery that controls the redox balance.