Artículo de revista
Estrés oxidativo, prooxidantes y enfermedad de Crohn
Fecha
2006Autor
Tapia S., Alexis
Araya, Magdalena
Institución
Resumen
The frequency of Crohn disease shows a significant increase in the
last century. Affected patients show a misbalance between production of free radicals and anti
oxidant defenses. Thus, one of the increasingly accepted htypotheses to explain the origin of this
disease, is the oxidative stress that occurs in the intestinal mucosa. Dietary factors including self
administered vitamin and mineral supplemets may play a role, especially when they contain
excessive amounts of iron and copper, known for their prooxidant capacities. Unfortunately,
little is known about how these metals may influence the antioxidant defenses in the intestinal
mucosa. This article reviews the literature on the why and how these elements may act on
individuals susceptible to develop Crohm disease, including the evidence supporting the
hypothesis that oxidative stress in the intestinal mucosa is an important pathogenetic factor.