Artículo de revista
New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents
Fecha
2012Registro en:
DALTON TRANSACTIONS Volume: 41 Issue: 5 Pages: 1534-1543 Published: 2012
DOI: 10.1039/c1dt11519g
Autor
Demoro, Bruno
Sarniguet, Cynthia
Sánchez Delgado, Roberto
Rossi, Miriam
Liebowitz, Daniel
Caruso, Francesco
Olea Azar, Claudio
Moreno, Virtudes
Medeiros, Andrea
Comini, Marcelo A.
Otero, Lucía
Gambino, Dinorah
Institución
Resumen
In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasites, and particularly against African Trypanosomiasis, whose etiological agent is Trypanosoma brucei, organoruthenium compounds with bioactive nitrofuran containing thiosemicarbazones (L) as co-ligands were obtained. Four ruthenium(II) complexes with the formula [Ru(2)(p-cymene)(2)(L)(2)]X(2), where X = Cl or PF(6), were synthesized and the crystal structures of two of them were solved by X-ray diffraction methods. Two of the complexes show significant in vitro growth inhibition activity against Trypanosoma brucei brucei and are highly selective towards trypanosomal cells with respect to mammalian cells (J774 murine macrophages). These promising results make the title organoruthenium compounds good lead candidates for further developments towards potential antitrypanosomal organometallic drugs.