Artículos de revistas
Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat
Fecha
1999-03-26Registro en:
LIFE SCIENCES 64 (18): 1603-1612
0024-3205
Autor
Jalil Milad, Jorge
Ebensperger González, Roberto
Meléndez Vergara, Jaime
Acevedo, E.
Sapag Hagar, Mario
González Jara, Fabián Rodrigo
Gálvez, Anita
Pérez Montes, Viviana
Lavandero González, Sergio
Institución
Resumen
There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and a-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drugs in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, a-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-I contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.