Artículos de revistas
Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
Fecha
2006-08-15Registro en:
BIOORGANIC & MEDICINAL CHEMISTRY 14(16):5673-5677
0968-0896
Autor
Aguirre, María C.
Delporte Vergara, Carla
Backhouse Erazo, Nadine
Erazo, Silvia
Letelier Muñoz, María Eugenia
Cassels Niven, Bruce
Silva, Ximena
Alegría, Sergio
Negrete Córdova, Rosa
Institución
Resumen
Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2 alpha-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin.