CHEMICAL BONDING OF METRONIDAZOLE SEMIESTERS WITH STARCH

dc.creatorCordano, G.
dc.creatorYung Engel, Carlos
dc.creatorMuñoz, S.
dc.creatorMarrese Cabezas, Juan Carlos
dc.creatorMuñoz de la Peña Bueno, Amalia
dc.creatorMedina, Jorge
dc.date.accessioned2009-05-29T12:23:42Z
dc.date.available2009-05-29T12:23:42Z
dc.date.created2009-05-29T12:23:42Z
dc.date.issued1985-12
dc.identifierBOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA 34(4):279-285
dc.identifier0366-1644
dc.identifierhttps://repositorio.uchile.cl/handle/2250/120649
dc.description.abstractThe incorporation of [1-(2-hydroxyethyl)-2-methyl-5-nitro-imidazole] (metronidazole), modified by treatment with succinic, glutaric and phtalic anhydrides on starch was studies. For the reaction the starch was previously activated with pyridine-water until gelification in the presence of dicyclohexylcarbodiimide (DCC) as a dehydrant agent and N,N,-dimethylaminopyridine (DAMP) as a catalyst. Incorporation of metronidazole on starch ranged up to 21.20%. Products were characterized by IR spectroscopy, and the incorporated drug determined by releasing the nitrate ion from the metronidazole followed by its quantification by a colorimetric technique.
dc.languagees
dc.publisherSOCIEDAD CHILENA DE QUIMICA
dc.subjectSTARCH
dc.titleCHEMICAL BONDING OF METRONIDAZOLE SEMIESTERS WITH STARCH
dc.typeArtículo de revista


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