Artículos de revistas
Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies
Fecha
2005-06Registro en:
LETTERS IN DRUG DESIGN & DISCOVERY V.: 2, issue: 4, p.: 294-301: JUN 2005
1570-1808
Autor
Olea Azar, Claudio
Rigol Olsen, Carolina
Mendizábal Emaldía, Fernando
Cerecetto, Hugo
Di Maio, R.
González, Mercedes
Porcal, Williams
Morello Casté, Antonio
Repetto Scaramelli, Yolanda
Maya Arango, Juan
Institución
Resumen
In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide
derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed.
Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction
processes. Effects on the parasitic respiration were studied.