Effects of simple and angular chromones on tumor cell respiration

Araya Maturana, Ramiro; Heredia Moya, Jorge; Donoso Tauda, Oscar; Vera Castillo, Mario Francisco; Toledo Hernández, Jorge; Pavani, Mario; Pessoa Mahana, Hernán; Weiss López, Boris; Ferreira Parker, Jorge

Artículo de revista

Fecha

2008

Registro en:

NATURAL PRODUCT COMMUNICATIONS 3(4):519-524

1934-578X

https://repositorio.uchile.cl/handle/2250/120523

Autor

Araya Maturana, Ramiro

Heredia Moya, Jorge

Donoso Tauda, Oscar

Vera Castillo, Mario Francisco

Toledo Hernández, Jorge

Pavani, Mario

Pessoa Mahana, Hernán

Weiss López, Boris

Ferreira Parker, Jorge

Institución

Universidad de Chile

Resumen

A set of structurally related compounds incorporating a chromone moiety as an essential component of their structures were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. A tentative structure-activity relationship was found for this family of substances, suggesting that a Michael addition at C-1 is involved in the mechanism that provokes the activities.

Materias

Tumor cell respiration

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