Artículo de revista
A quantum-chemical and experimental study of the hallucinogen (k)- 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON)
Fecha
1987-06-05Registro en:
Eur. J. Med. Chem. 22, 433-437, 1987.
0223-5234.
Autor
Gómez Jeria, Juan
Cassels Niven, Bruce
Saavedra Aguilar, Juan Carlos
Institución
Resumen
The electronic structure of 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) was calculated at
the CND0/2 level, and the racemic compound was synthesized and found to be hallucinogenic at doses of 4 mg. DON
differs from its similarly active congeners in that a hydrophilic nitro group replaces lipophilic substituents at C-4 of the
benzene ring. The implications for the mechanism of serotonin receptor binding of these drugs are discussed.