Artículo de revista
Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway
Fecha
2005-07-07Registro en:
NEURON, Volume: 47, Issue: 1, Pages: 43-56, 2005
0896-6273
Autor
Cavodeassi, Florencia
Carreira-Barbosa, Filipa
Young, Rodrigo M.
Concha, Miguel L.
Allende Connelly, Miguel
Houart, Corinne
Tada, Masazumi
Wilson, Stephen W.
Institución
Resumen
During regional patterning of the anterior neural plate, a medially positioned domain of cells is
specified to adopt retinal identity. These eye field cells remain coherent as they undergo
morphogenetic events distinct from other prospective forebrain domains. We show that two branches
of the Wnt signaling pathway coordinate cell fate determination with cell behavior during eye field
formation. Wnt/β-catenin signaling antagonizes eye specification through the activity of Wnt8b and
Fz8a. In contrast, Wnt11 and Fz5 promote eye field development, at least in part, through local
antagonism of Wnt/β-catenin signaling. Additionally, Wnt11 regulates the behavior of eye field cells,
promoting their cohesion. Together, these results allow us to postulate a model in which Wnt11 and
Fz5 signaling promotes early eye development through the coordinated antagonism of signals that
suppress retinal identity and promotion of coherence of eye field cells.