Artículo de revista
Control of Cell Migration in the Zebrafish Lateral Line: Implication of the Gene “Tumour- Associated Calcium Signal Transducer,” tacstd
Fecha
2006-03-21Registro en:
DEVELOPMENTAL DYNAMICS, Volume: 235, Issue: 6, Pages: 1578-1588, 2006
1058-8388
Autor
Villablanca, Eduardo J.
Renucci, Armand
Sapède, Dora
Lec, Valérie
Soubiran, Fabien
Sandoval, Pablo C.
Dambly-Chaudiere, Christine
Ghysen, Alain
Allende Connelly, Miguel
Institución
Resumen
The sensory organs of the zebrafish lateral-line system (neuromasts) originate from migrating primordia
that move along precise pathways. The posterior primordium, which deposits the neuromasts on the body
and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail.
This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, and
by its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe another
zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a
membrane protein that is homologous to the TACSTD1/2 mammalian proteins. Inactivation of the zebrafish
tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the
deposition process.