Artículo de revista
CNTF, a pleiotropic cytokine: emphasis on its myotrophic role
Fecha
2004-12Registro en:
BRAIN RESEARCH REVIEWS, V.: 47, issue: 1-3, p. 161-173, DEC, 2004.
0165-0173
Autor
Vergara Montecinos, Cecilia
Ramírez, Beatriz
Institución
Resumen
Ciliary neurotrophic factor (CNTF) is a cytokine whose neurotrophic and differentiating effects over cells in the central nervous system
(CNS) have been clearly demonstrated. This article summarizes the general characteristics of CNTF, its receptor and the signaling pathway
that it activates and focuses on its effects over skeletal muscle, one of its major target tissues outside the central nervous system. The evidence
for the existence of other molecules that signal through the same complex as CNTF is also reviewed.