masterThesis
Eficacia diagnostica del ácido láctico en liquido cefalorraquídeo en meningitis postclipaje de aneurisma cerebral y hemorragia subaracnoidea
Fecha
2012Autor
Gómez Gualdrón, Sergio Roldan
Rincon Riano, Diana Nathalie
Institución
Resumen
The lactic acid concentration in cerebrospinal fluid (CSF) was measured in patients with
suspected meningitis after aneurysmal clipaje for spontaneous subarachnoid hemorraghe. It was measured
in a prospective way during a three years period time. In total were analyzed 32 samples of CSF,
the lactic acid concentration was compared against culture of CSF. The CSF culture was positive in 5
patients, with a meningitis prevalence of 15%. We use a cut-off value of 4 mmol/L for lactic acid and
we find a sensitivity of 80%, specificity of 52%, VPP of 23%, VPN of 93% and a positive LHR of 1.66
with a posttest probability of 15% for the lactic acid concentration in CSF for the diagnosis of meningitis
in patients with aneurysmal clipaje and subarachnoid hemorrhage. The acid lactic concentration
in CSF has a limited diagnostic efficacy in patients with subarachnoid hemorrhage and suspected
postquirurgical meningitis.