dc.creator | Patarroyo, Manuel E. | |
dc.creator | Patricia Alba, Martha | |
dc.creator | Curtidor, Hernando | |
dc.creator | Vanegas, Magnolia | |
dc.creator | Almonacid, Hannia | |
dc.creator | Patarroyo, Manuel A. | |
dc.date.accessioned | 2014-08-12T16:23:29Z | |
dc.date.available | 2014-08-12T16:23:29Z | |
dc.date.created | 2014-08-12T16:23:29Z | |
dc.date.issued | 2014 | |
dc.identifier | ISSN:1932-6203 | |
dc.identifier | http://repository.urosario.edu.co/handle/10336/8808 | |
dc.identifier | https://doi.org/10.1371/journal.pone.0088420 | |
dc.description.abstract | Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this similar to 300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria. | |
dc.language | eng | |
dc.publisher | Universidad del Rosario | |
dc.relation | PLOS ONE ISSN: 1932-6203 V. 9 N. 2 Feb 7, 2014 | |
dc.relation | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088420 | |
dc.relation | No. 2 | |
dc.relation | PLOS ONE | |
dc.relation | Vol. 9 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Abierto (Texto completo) | |
dc.rights | EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. | |
dc.source | instname:Universidad del Rosario | |
dc.source | reponame:Repositorio Institucional EdocUR | |
dc.title | Using the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria | |
dc.type | article | |