"Treating wounds under normal wound healing processes often require little or no intervention, consisting primarily of debridement, as during the inflammatory stage the cells clear the wound to healing. However wound care professionals face many challenges in treating acute wounds with impairment on healing such as burn injuries or chronic wounds like diabetic, vascular and pressure ulcers. Wound healing is a complex process of several stages that requires being free of complications. Then the goal of the wound treatment is to prevent or convert the impediments to healing and depends on the characteristics of the wound, like time, depth, extent, appearance of the surface and exudate, and quality of the periwound tissues. There are currently a wide variety of products available for skin wound treatment. The tissue engineered skin substitutes market offers a wide variety of solutions with different type of dressings that comprise skin grafts derived from allogeneic or xenogeneic sources, products of synthetic material, or a combination of these, to in vitro cultured tissue for epidermal and dermal replacement. Whereas cellular-based products affront issues of safety by the risks of disease transmission, post-implementation infection and immune system rejection, besides theprominent costs of the whole therapy, the synthetic skin dressings are being more demanded due to the low cost, easy availability, uniform composition and the avoiding of safety risks. This review is intended to help the clinician to suit the right cost-effective solution with the condition by providing information of evidence-based products for wound bed preparation and treatment made of synthetic matrix".