One of the current trends in computer science is the use of ontologies in Software Engineering. In this context, several academic and industrial works have used ontologies as mechanism for system requirements representation and automatic code generation. However, most of current works propose generic development platforms regardless the reuse of components for a specific domain. In this paper, a Model-Driven Development Framework, called SemanticWebBuilder (SWB) is presented. SWB provides an agile development platform for the Web application domain, where system requirements are modeled through ontologies and from this knowledge representation, the infrastructure of the system is automatically generated. The resultant system can be extended by reusing of code, thus allowing to build complex systems in a short time. Moreover, system data is represented as RDF triples, making this data available in the Semantic Web. SWB has been widely used to develop Web applications for several government dependencies in Mexico.