Artículos de revistas
Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy – CADASIL
Autor
Brondani, Rosane
Almeida, Andrea Garcia
de Araújo, Vicenzo Zarpellon
Bianchin, Larissa
Mota, Suelen Mandelli
Krammer, Bárbara Reis
Marafon, Martina Camerini
Mazzocato, Eduardo de Carvalho
Bianchin, Marino Muxfeldt
Resumen
We report here neuroimaging findings of a 41 years-old female with molecular diagnosis of CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy). CADASIL, the most common form of hereditary stroke, is characterized by headaches and relapsing strokes. More than 95% of patients present mutations of NOTCH3 gene. MRI, the best neuroimaging modality to investigate CADASIL can show lacunar infarcts and less-well demarcated T2 weighted hyperintensities characteristically located in subcortical white matter. There is no specific treatment for CADASIL. Anti-platelet agents such as aspirin might help to prevent new strokes. Other symptoms, like headache, seizures, or other neuropsychiatric manifestations should be appropriately treated.