Artículos de revistas
Reproductive actions of prolactin mediated through short and long receptor isoforms
Fecha
2014-01Registro en:
Devi Sangeeta, Y.; Halperin, Julia; Reproductive actions of prolactin mediated through short and long receptor isoforms; Elsevier Ireland; Molecular and Cellular Endocrinology; 382; 1; 1-2014; 400-410
0303-7207
CONICET Digital
CONICET
Autor
Halperin, Julia
Devi Sangeeta, Y.
Resumen
Prolactin (PRL) is a polypeptide hormone with a wide range of physiological functions, and is critical for female reproduction. PRL exerts its action by binding to membrane bound receptor isoforms broadly classified as the long form and the short form receptors. Both receptor isoforms are highly expressed in the ovary as well as in the uterus. Although signaling through the long form is believed to be more predominant, it remains unclear whether activation of this isoform alone is sufficient to support reproductive functions or whether both types of receptor are required. The generation of transgenic mice selectively expressing either the short or the long form of PRL receptor has provided insight into the differential signaling mechanisms and physiological functions of these receptors. This review describes the essential finding that both long and short receptor isoforms are crucial for ovarian functions and female fertility, and highlights novel mechanisms of action for these receptors.