Artículos de revistas
Capturing chaotic chromosomes: Pairing in action
Fecha
2018-03Registro en:
Bertucci, Micka C.; Das, Arunika; Fitzgerald, Harriet C.; Goszczynski, Daniel Estanislao; Capturing chaotic chromosomes: Pairing in action; Wiley-liss, Div John Wiley & Sons Inc; Molecular Reproduction and Development; 85; 3; 3-2018; 173-173
1040-452X
CONICET Digital
CONICET
Autor
Bertucci, Micka C.
Das, Arunika
Fitzgerald, Harriet C.
Goszczynski, Daniel Estanislao
Resumen
Accurate chromosome segregation is critical for the formation of haploid gametes, and therefore healthy offspring. Errors in segregation result in aneuploidy, which increases exponentially with maternal age (Hassold and Hunt, 2001). Maternally aged mouse oocytes were recently found to exhibit premature sister chromatid separation due to reduced levels of Securin, an essential regulator of sister chromatid cohesion (Nabti et al, 2017). This landmark finding was facilitated by using chromosome spreads that allow for the visualization of meiotic processes, such as recombination, synapsis, crossing over, and cohesion. This powerful technique is easy to perform and analyze, and allows for the identification of markers for different processes, including DNA damage and repair.