Artículos de revistas
Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
Fecha
2009-01Registro en:
Maggini, Julian; Raiden, Silvina Claudia; Salamone, Gabriela Veronica; Trevani, Analía Silvina; Geffner, Jorge Raúl; Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors; Frontiers in Bioscience; Frontiers in Bioscience; 14; 6; 1-2009; 2372-2385
1093-9946
CONICET Digital
CONICET
Autor
Maggini, Julian
Raiden, Silvina Claudia
Salamone, Gabriela Veronica
Trevani, Analía Silvina
Geffner, Jorge Raúl
Resumen
As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a number of agents such as cytokines, pathogens and environmental stressors. Apoptosis of neutrophils is central to homoeostasis and the resolution of inflammation. Recent studies have highlighted the complex convergence of different pathways in the regulation of neutrophil survival. This review focuses on the mechanisms involved in the induction and regulation of neutrophil apoptosis.